Keywords: نوع وحشی; AEP; asparagine endopeptidase; AD; Alzheimer's disease; AEP KO; AEP knockout; WT; wildtype; MWM; Morris water maze; fEPSP; field excitatory postsynaptic potential; PP; perforant pathway; DG; dentate gyrus; TBS; theta burst stimulation; LTP; long-term po
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Keywords: نوع وحشی; AraC; cytosine arabinoside; αSyn; α-synuclein; BSA; bovine serum albumin; Con; control; CQ; chloroquine; DIV; days in vitro; DMSO; dimethyl sulfoxide; E. coli; Escherichia coli; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; G
Keywords: نوع وحشی; Sensory nerves; Transient receptor potential channels; Neuropeptides; Skin inflammation; Peripheral vasculature; ATP; adenosine triphosphate; CFA; Complete Freund's Adjuvant; CGRP; calcitonin gene related peptide; CLR; calcitonin receptor-like receptor; C
Keywords: نوع وحشی; ANOVA; analysis of variance; BDNF; Brain-derived neurotrophic factor; CORT; corticosterone; CS; conditioning stimulus; GR; glucocorticoid receptor; HET; heterozygous; HET CORT; HET rats receiving CORT; HPA; hypothalamic-pituitary axis; MR; mineralocorti
Keywords: نوع وحشی; T2DM; type II diabetes mellitus; PI3K; phosphatidyl inositol-3-kinase; (PKC)-ζ; protein kinase C zeta; Akt; protein kinase B; GLUT4; glucose transporter 4; GK/Gyk; glycerol kinase (GK in humans and Gyk in mice); WT; wildtype; KO; knockout; PTP; protein t
Keywords: نوع وحشی; AMP; adenosine monophosphate; FBPase; fructose-1,6-bisphosphatase; FBP1; liver FBPase; FBP2; muscle FBPase; F1,6P2; fructose-1,6-bisphosphate; F6P; fructose-6-phosphate; FITC; fluorescein isothiocyanate; GSK3; glycogen synthase kinase 3; WT; wildtype; Fru
Keywords: نوع وحشی; TMV; tobacco mosaic virus; CP; coat protein; wt; wildtype; SPP; sodium potassium phosphate; OAs; origin of assembly; DS; disk-like structure; TMV; Mineralisation; Self-assembly; In vitro; E. coli;
Keywords: نوع وحشی; AP-1; activator protein 1; Dusp; dual-specificity phosphatase; Egr1; early growth response protein 1; ERK; extracellular signal regulated kinase; F2-KO mice; flotillin-2 knockout mice; Flot-1; flotillin-1; Flot-2; flotillin-2; HB-EGF; Heparin Binding-EGF;
Keywords: نوع وحشی; FMDV; foot-and-mouth disease virus; Lbpro; leader proteinase; sLbpro; shortened leader proteinase (lacking 6 C-terminal amino acids); wt; wildtype; CTE; C-terminal extension; eIF; eukaryotic initiation factor; Papain-like cysteine proteinase; Host cell sh
Keywords: نوع وحشی; MCs; mast cells; MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; WT; wildtype; SCI; spinal cord injury; mMCP4; mouse mast cell protease 4; BMS; basso mouse scale; GFAP; glial fibrillary acidic protein; MBP; myelin basic protein; Ib
Keywords: نوع وحشی; KO; Kv1.3-null (â/â); MOE; main olfactory epithelium; OB; olfactory bulb; OSN; olfactory sensory neuron; PBS; phosphate buffered saline; SEM; standard error of the mean; WT; wildtype; Kv1.3; Plasticity; Odor enrichment; Trigeminal;
Keywords: نوع وحشی; AA; arachidonic acid; AD; Alzheimer's disease; ANOVA; analysis of variance; DA; dopamine; DAB; 3,3â²-diaminobenzidine; DOPAC; dihydroxyphenylacetic acid; EDTA; ethylenediaminetetraacetic acid; GFAP; glial acidic fibrillary protein; HETE; hydroxyeicosat
T-DNA associated reciprocal translocation reveals differential survival of male and female gametes
Keywords: نوع وحشی; Translocation; Insertion line; T-DNA; Gene dosage; Unbalanced chromosome; CCCH zinc finger; dHET; Double heterozygous mutant of AtC3H6 and AtC3H68; T-DNA; Transfer DNA; Col; Arabidpsis thaliana Columbia ecotype; PCR; Polymerase chain reaction; RT-PCR; Rev
One step ahead: miRNA-34 in colon cancer-future diagnostic and therapeutic tool?
Keywords: نوع وحشی; AOM; azoxymethane; APC; adenomatous polyposis coli; BTG-4; B-cell translocation gene; CAC; colitis associated cancer; CSCs; cancer stem cells; CRC; colorectal cancer; DSS; dextran sodium sulfate; GSK-3; glycogen synthase kinase-3; EMT; epithelial-mesenchy
Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke
Keywords: نوع وحشی; NK; natural killer; PBMCs; peripheral blood mononuclear cells; CXCL8; interleukin-8; CXCR2; CXC chemokine receptor 2; IFN; interferon; miR; microRNA; AHA/ASA; American Heart Association/American Stroke Association; DWI; diffusion-weighted imaging; mRS; mo
Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy
Keywords: نوع وحشی; (ERK); extracellular signal-regulated kinase; (MAPK); mitogen-activated protein kinase; (TEY); Threonine-Glutamate-Tyrosine; (tTa); tetracycline trans-activator; (TAC); transverse aortic coarctation; (FS); fractional shortening; (LVIDd, LVIDs); left ventr
IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal
Keywords: نوع وحشی; Arg1; Arginase 1; α-SMA; alpha-smooth muscle actin; ASO; antisense oligonucleotide; BW; body weight; CCL2; chemokine (C-C motif) ligand 2; CCl4; carbon tetrachloride; Col1a1; procollagen α1(I) transcript; DAPI; 4,6-diamidino-2-phenylindole; DKO; doubl
Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet
Keywords: نوع وحشی; T2D; type 2 diabetes; VAT; visceral adipose tissue; IR; insulin resistance; LFD; low fat diet; HFD; high fat diet; ATM; adipose tissue macrophage; DIO; diet induced obesity; BMDM; bone marrow derived macrophage; WT; wildtype; eWAT; epididymal white adipos
Role of GPx3 in PPARγ-induced protection against COPD-associated oxidative stress
Keywords: نوع وحشی; COPD; chronic obstructive pulmonary disease; ROS; reactive oxygen species; GSH; glutathione; GPx; GSH peroxidase; PPARγ; Peroxisome proliferator-activated receptor γ; NF-κB; nuclear factor-κB; CSE; cigarette smoke extract; HBE; human bronchial epithel
Genetic Modulation of HSPA1A Accelerates Kindling Progression and Exerts Pro-convulsant Effects
Keywords: نوع وحشی; CA1 and CA3; cornu ammonis region 1 and 3; EEG; electroencephalography; HMGB1; high-mobility group box 1; hsp70; heat shock protein 70; Iba1; ionized calcium binding adaptor molecule 1; iNOS; nitric oxide synthase; PTZ; pentylenetetrazol; TG; transgenic;
Roles of TRPV1 and TRPA1 in Spontaneous Pain from Inflamed Masseter Muscle
Keywords: نوع وحشی; AUs; facial action units; CPP; conditioned place preference; H2O2; hydrogen peroxide; HODE; 13(S)-hydroxyoctadecadienoic acid; KO; knockout; MGS; mouse grimace scale; OLAMs; Oxidized linoleic acid metabolites; TRPA1; transient receptor potential ankyrin 1
A new method measuring the interaction of radiotracers with the human P-glycoprotein (P-gp) transporter
Keywords: نوع وحشی; AUC; area under the curve; BCRP; breast cancer resistance protein; Ki; equilibrium inhibitory constant; hMDR1; human multiple drug resistance 1; MDCKII; Madin-Darby Canine Kidney cell line; MRP-1; multiple drug resistance protein 1; PET; positron emission
Neurodegeneration in the olfactory bulb and olfactory deficits in the Ccdc66 -/- mouse model for retinal degeneration
Keywords: نوع وحشی; AG; astroglia; Ccdc66 -/-; Ccdc66-deficient; Ccdc66 +/+, WT; wildtype; CTX; cortex; De; dendrite; EPL; external plexiform layer; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GL; glomerular layer; gPRA; generalized progressive retinal atrophy; ioD; int
The orphan nuclear receptor TLX regulates hippocampal transcriptome changes induced by IL-1β
Keywords: نوع وحشی; TLX; orphan nuclear receptor tailless homolog; IL-1β; interleukin-1 beta; TNF; tumor necrosis factor; NPCs; neural progenitor cells; DG; dentate gyrus; LTP; long term potentiation; P; post-natal day; KO; knockout; WT; wildtype; PBS; phosphate buffered sa
Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice
Keywords: نوع وحشی; ABHD14A; alpha/beta hydrolase domain containing 14a; ABHD14B; alpha/beta hydrolase domain containing 14b; ACV; acyclovir; Bphl; biphenyl hydrolase-like protein; KO; knockout; PepT1; peptide transporter 1 (SLC15a1); PepT2; peptide transporter 2 (SLC15a2);
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy
Keywords: نوع وحشی; MPS; α-methyl-α-phenylsuccinimide; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; BSA; Bovine serum albumin; CNS; Central nervous system; DRS; Dent's Ringer solution; FTLD; Frontotemporal lobar degeneration; MOO; Multi-objective optimisati
LXR agonists promote the proliferation of neural progenitor cells through MEK-ERK pathway
Keywords: نوع وحشی; Neural progenitor cells; Proliferation; LXR agonists; GW3965; LXR623; ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1; ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1; AD; Alzheimer diseases; CNS; central nervous system; DMEM; Dulbe
Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor
Keywords: نوع وحشی; β-ABA; β-aminobutyric acid; β-AIBA; β-aminoisobutyric acid; GlyR; glycine receptor; LBD; ligand-binding domain; MBS; Modified Barth's Saline; Popen; probability of channel being open; SEM; standard error of the mean; Ï; dwell-time; TM; transmembran
Compound heterozygous KCNQ1 mutations (A300T/P535T) in a child with sudden unexplained death: Insights into possible molecular mechanisms based on protein modeling
Keywords: نوع وحشی; aa; amino acid; BWA; Burrows-Wheeler aligner; CaM; calmodulin; CPR; cardiopulmonary resuscitation; DNA; deoxyribonucleic acid; ECG; electrocardiogram; GOF; gain of function; KCNE1; potassium voltage-gated channel subfamily E member 1; Kv7.1; voltage-gated
Age, sex, and TNF associated differences in the gut microbiota of mice and their impact on acute TNBS colitis
Keywords: نوع وحشی; Gut microbiota; Inflammation; Sex-differences; Mouse models; TNF; tumor necrosis factor; WT; wildtype; Tnfâ/â; Â TNF knockout; IBD; Inflammatory Bowel Disease; CD; Crohn's Disease;
Research PaperMice with conditional NeuroD1 knockout display reduced aberrant hippocampal neurogenesis but no change in epileptic seizures
Keywords: نوع وحشی; SRS; spontaneous recurring seizures; TLE; temporal lobe epilepsy; GCL; granule cell layer; SGZ; subgranular zone; DG; dentate gyrus; YFP; yellow fluorescent protein; KA; kainic acid; Dcx; doublecortin; cKO; conditional knock-out; WT; wildtype; ND1; NeuroD
Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice
Keywords: نوع وحشی; ABR; auditory brainstem response; DT; diphtheria toxin; DTR; DT receptor; EDTA; ethylenediaminetetraacetic acid; EF-2; elongation factor-2; H&E; hematoxylin and eosin; HB-EGF; heparin-binding epidermal growth factor-like growth factor; HC; hair cell; HEPE
Nab2 maintains thymus cellularity with aging and stress
Keywords: نوع وحشی; Nab2; NGFI-A binding protein 2; Egr; Early growth response gene; WT; wildtype; SP; single-positive thymocytes; DN; double-negative thymocytes; DP; double-positive thymocytes; Immediate early gene; NGFI-A binding protein; Early growth response gene; Thymus
Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation
Keywords: نوع وحشی; Acetylation; GCN5; Mitochondria; SIRT1; Deacetylase; PGC-1α; AMP; adenosine monophosphate; Ca2+; calcium; CBP; CREB-binding protein; Cre-MCK; creatine kinase promoter; CHO; carbohydrate; DAC; deacetylase; ETC; electron transport chain; ExT; endurance exe
Original ArticleActivation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma
Keywords: نوع وحشی; Sex-determining region on Y chromosome; Liver; Transgenic; Sex; Sox9; HCC; hepatocellular carcinoma; TG; transgenic; WT; wildtype; SRY; sex-determining region on Y chromosome; DEN; N-nitrosodiethylamine; PDGFRα; platelet-derived growth factor receptor α
Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection
Keywords: نوع وحشی; eIF; eukaryotic initiation factor; FMDV; foot-and-mouth disease virus; HRV; human rhinovirus; IRES; internal ribosome entry site; Lpro; Leader proteinase; rmsd; root mean squared deviation; wt; wildtype; Chymotrypsin-like cysteine proteinase; Host cell sh
A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14
Keywords: نوع وحشی; CDS; coding sequence; co-IP; co-immunoprecipitation; FBS; fetal bovine serum; FMRP; fragile X mental retardation protein; KO; knockout; PBS; phosphate-buffered saline; PVDF; polyvinylidene difluoride; RBM14; RNA-binding protein 14; RIP; RNA immunoprecipit
Research PaperA rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders
Keywords: نوع وحشی; ASD; autism spectrum disorder; NDD; neurodevelopmental disorders; ADHD; attention deficit hyperactivity disorders; WT; wildtype; SNPs; single nucleotide polymorphism; SFARI; Simons Foundation Autism Research Initiative; GABA; γ-aminobutyric acid; RNAi; R
Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice
Keywords: نوع وحشی; ASD; Autism Spectrum Disorder; KO; knockout; MWT; Morris water task; NIH; novelty-induced hypophagia; PPI; prepulse inhibition; SEM; standard error of the mean; WT; wildtype; ZnT3; zinc transporter 3; Sex differences; Vesicular zinc; Synaptic zinc; Motor
Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1
Keywords: نوع وحشی; α,β-meATP; α,β-methylene-ATP; AP; action potential; DRG; dorsal root ganglia; CGRP; calcitonin gene-related peptide; FHM1; familial hemiplegic migraine type-1; HCN; hyperpolarization-activated cyclic nucleotide-gated channel; Ih; hyperpolarization-act
Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma
Keywords: نوع وحشی; CI; confidence interval; GEM; Genes, Environment, and Melanoma; OR; odds ratio; SSM; superficial spreading melanoma; WT; wildtype;
Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating
Keywords: نوع وحشی; ANOVA; analysis of variance; KO; knockout; nNOS; neuronal nitric oxide synthase; PPI; pre-pulse inhibition; WT; wildtype; GTPases; NMDA; prepulse inhibition; learning and memory; sensory;
The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development
Keywords: نوع وحشی; ARE; antioxidant response element; bp; base pair; bZIP; basic leucine zipper; ChIP; chromatin immunoprecipitation; CNC; Cap'n'Collar (CNC); hpe; hours post exposure; hpf; hours post fertilization; KO; knockout; NFE2; Nuclear Factor (Erythroid-Derived
Function of brain α2B-adrenergic receptor characterized with subtype-selective α2B antagonist and KO mice
Keywords: نوع وحشی; ADHD; attention deficit hyperactivity disorder; CNS; central nervous system; HEK; human embryonic kidney; KO; knockout; PPI; pre-pulse inhibition; WT; wildtype; adrenergic; α2B-receptor; sensorimotor; stereotypy; compulsivity;
TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene
Keywords: نوع وحشی; 3D; three dimensional; Ad-EGFP; adenovirus vector encoding enhanced green fluorescent protein; APOE; apolipoprotein E; Aqp1; aquaporin 1; Arg; arginine; bHLH; basic helix-loop-helix; BMDSC; bone marrow-derived stem cell; BMP; bone morphogenetic protein; B
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle
Keywords: نوع وحشی; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²AMP activated protein kinase; ANOVA; Analysis of Variance; ATG; autophagy related gene; ATP; adenosine triphosphate; BCA; bicinchoninic acid; BSA; bovine serum albumin
Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP
Keywords: نوع وحشی; 5-H(p)ETE; 5S-hydro(pero)xy-6,8,11,14(E,Z,Z,Z)-eicosatetraenoic acid; 6-trans-LTB4; 5S,12R-dihydroxy-6,8,10,14(E,E,E,Z)-eicosatetraenoic acid; 6-trans-12-epi-LTB4; 5S,12S-dihydroxy-6,8,10,14-(E,E,E,Z)-eicosatetraenoic acid; Aa; amino acid; AA; arachidonic
Research ArticleGut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4
Keywords: نوع وحشی; BA; bile acid; Asbt; apical sodium-dependent bile acid transporter; KO; knock-out; iKO; intestinal-specific knock-out; WT; wildtype; CA; cholic acid; CDCA; chenodeoxycholic acid; MCA; muricholic acid; UDCA; urodeoxycholic acid; Gut microbiota; Intestinal
TRPC1 regulates fMLP-stimulated migration and chemotaxis of neutrophil granulocytes
Keywords: نوع وحشی; DAG; diacylglycerol; fMLP; N-formyl-methionine-leucine-phenylalanine; FPR; N-formyl-methionine-leucine-phenylalanine receptor; IP3; inositol 1,4,5-trosphosphate; PLC; phospholipase C; ROCE; receptor operated calcium entry; SOCE; store operated calcium ent
Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model
Keywords: نوع وحشی; ANOVA; analysis of variance; BSA; bovine serum albumin; Ko; knockout; MCA; middle cerebral artery; PB; phosphate buffer; PFA; paraformaldehyde; TBI; traumatic brain injury; Wt; wildtype; conditional p53 knockout; stroke; neuroprotection;