کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8650680 | 1571135 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
No detriment in taste response or expression in offspring of mice fed representative levels of sucrose or non-caloric sucralose while pregnant
ترجمه فارسی عنوان
هیچ تاثیری در واکنش طعم و مزه ای در فرزندان موش هایی که مقادیر سطح سوکرروز یا سوکارلوس غیر کالری را در دوران بارداری تغذیه نمی کنند
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کلمات کلیدی
NHANESAcesulfame-KFDAT1R3HEDADI - NAMEUnited States of America - ایالات متحده آمریکاUSA - ایالات متّحدهٔ آمریکاPregnancy - بارداریNational Health and Nutrition Examination Survey - بررسی بهداشت و تغذیه ملیAcceptable daily intake - دریافت روزانه قابل قبولHuman equivalent dose - دوز معادل انسانیDiet - رژیم غذاییFood and Drug Administration - سازمان غذا و داروSucrose - ساکارزSucralose - ساکرالوزSweet - شیرینTaste - مزه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
Recent studies in mice indicate that consumption of acesulfame K (a high intensity sweetener) while pregnant, can lead to deficits in taste or enhanced sweet consumption in the offspring, leading to concerns the same may be common in human populations. However, this work employed a relatively unpopular sweetener, fed in quantities amounting to over 20Â Ã the FDA's Acceptable Daily Intake (ADI). The aims of this study were to test the effects of sucralose, the USA's most popular high intensity sweetener, along with sucrose, on the taste system of the offspring of mice supplemented at a level commensurate with ADIs while pregnant. The hypothesis was that feeding a dam intensely sweet solutions would produce offspring with enhanced response to sweet taste, when compared to offspring of dams given only water. Females were mated following a 4-week period in which one group was given a measured ration of sucrose or sucralose in addition to chow and water, with the control group given chow and water only. Sucrose and sucralose solutions were removed two weeks after parturition to prevent direct consumption by the offspring. The offspring at 8Â weeks of age for both the sucrose and sucralose supplementation showed no change in their taste response to sucrose or sucralose. No effect of maternal sweet supplementation was detected at the taste bud level, with fungiform taste bud density and taste bud gene expression remaining unchanged. Overall, this study suggests that sucrose and sucralose consumption at human-relevant levels during pregnancy and lactation do not produce any long-term changes to the offspring's peripheral taste system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 184, 1 February 2018, Pages 39-45
Journal: Physiology & Behavior - Volume 184, 1 February 2018, Pages 39-45
نویسندگان
Ezen Choo, Robin Dando,