کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
866362 1470966 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir
ترجمه فارسی عنوان
سنتز و استفاده از یک پلیمر مولکولی تحت تاثیر قرار برای تعیین ولتاژ تشخیص فامسیکلوویر
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• MIP modified carbon paste was prepared for famciclovir.
• Computational studies for the pre-polymerization mixture binding energy was tested.
• The optimum ratio of IMP for FCV and MAA is (1:4).
• A linear response was obtained in the range of 2.5×10−6–1.0×10−3 M.
• MIP was applied for voltammetric assay of FCV in pure solutions and dosage form.

A molecularly imprinted polymer (MIP) was synthesized and applied as additive within a carbon paste electrode for the cyclic voltammetric determination of famciclovir (FCV). Complementary computational studies were performed to study the intermolecular interactions in the pre-polymerization mixture. Derived from the computational studies, four MIP ratios were synthesized and their performance was evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was selected. A linear response was obtained in the range of 2.5×10−6–1.0×10−3 M with a limit of detection at 7.5×10−7 M. Finally, the developed MIP–voltammetry system was successfully applied for the determination of FCV in pure solutions and pharmaceutical preparations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 65, 15 March 2015, Pages 108–114
نویسندگان
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