کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8673566 | 1578844 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Childhood Roots of Cardiovascular Disease Disparities
ترجمه فارسی عنوان
ریشه های کودکی اختلالات بیماری قلبی عروقی
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کلمات کلیدی
IL-6AAPAHAACEIMTSES - آنAmerican Academy of Pediatrics - آکادمی آمریکایی اطفالAmerican Heart Association - انجمن قلب آمریکاinterleukin 6 - اینترلوکین 6cardiovascular disease - بیماری قلب و عروقیAdverse childhood experience - تجربه دوران کودکی متضادCVD - رسوب دهی شیمیایی بخار body mass index - شاخص توده بدنBMI - شاخص توده بدنیIntima-media thickness - ضخامت Intima-mediaMESA - مازاMulti-Ethnic Study of Atherosclerosis - مطالعه چند قومی آترواسکلروزsocioeconomic status - وضعیت اجتماعی و اقتصادی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
A recent national review of the social determinants of cardiovascular disease (CVD) underscored the growing recognition that poor socioeconomic conditions early in life place children at higher risk for CVD as adults. There is growing evidence that chronic elevation of allostatic load as a consequence of high levels of early childhood stress can trigger early atherosclerotic changes in children independently of behaviors. Elevated levels of circulating cortisol have been documented in children as young as 4 years who were raised in highly stressful circumstances. Chronic elevation of cortisol is associated with increased release of inflammatory proteins such as interleukin 6, which can lead to fibrosis and scarring in the vessel walls of the arterial circulation, resulting in increased intima-media thickness. Increased intima-media thickness of the carotid artery has been found in individuals with low socioeconomic status as early as age 18 years and has been associated with increased CVD risk throughout the adult years. The American Academy of Pediatrics has recommended that it is the task of pediatricians and other health care professionals to screen for toxic stress among children during their early years and to take steps known to reduce stress reactivity, thereby helping these children to reduce their risk of early atherosclerotic changes and increased CVD throughout the life course.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 92, Issue 9, September 2017, Pages 1415-1421
Journal: Mayo Clinic Proceedings - Volume 92, Issue 9, September 2017, Pages 1415-1421
نویسندگان
Donald A. MD, PhD,