کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8675259 | 1578920 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual (Anticoagulant Plus Single Antiplatelet) vs Triple (Anticoagulant Plus Dual Antiplatelet) Antithrombotic Therapy - “Real World” Experience
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کلمات کلیدی
ACSDAPTCHADS2HAS-BLEDCHA2DS2-VASc - CHA2DS2-دارواشDES - ازdrug-eluting stent - استنت سم زداییBARC - بارکcoronary artery disease - بیماری عروق کرونرBleeding Academic Research Consortium - دانشگاه آزاد اسلامی واحد علوم و تحقیقاتdual antiplatelet therapy - درمان ضد تهاجمی دوگانهGastrointestinal - دستگاه گوارشAcute coronary syndrome - سندرم کرونری حادCAD - طراحی به کمک رایانه یا کَدAtrial fibrillation - فیبریلاسیون دهلیزی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Atrial fibrillation (AF) is a common arrhythmia that increases in prevalence with advancing age and in patients with coronary artery disease, revascularization, particularly with percutaneous coronary intervention (PCI), is also common. Both disease states have thrombosis as a core pathophysiologic process which requires treatment - low sheer stress thrombi in AF and intracoronary high sheer stress thrombi in PCI. For the 10-20% of patients who have both AF and undergo PCI, preventing thrombotic complications will require inhibition of both processes requiring simultaneous use of anticoagulation and antiplatelet therapy. There is a broad experience of combining oral anticoagulation therapy, used to prevent stroke and systemic embolization, in AF with dual antiplatelet therapy, used to prevent stent thrombosis and thrombotic coronary events. This “triple antithrombotic therapy” (TT) has been evaluated through many observation studies, both small and large. TT has more frequently been associated with a significant increase in bleeding events with non-significant reduction in thrombotic events. Current guidelines recommend shorter duration of TT, especially in patients with high risk of bleeding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Cardiovascular Diseases - Volume 60, Issues 4â5, JanuaryâFebruary 2018, Pages 531-536
Journal: Progress in Cardiovascular Diseases - Volume 60, Issues 4â5, JanuaryâFebruary 2018, Pages 531-536
نویسندگان
Mark B. Effron, C. Michael Gibson,