کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8678517 1579097 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intérêt de la recherche du polymorphisme de la thiopurine méthyltransférase et du dosage des métabolites chez les patients traités par azathioprine
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Intérêt de la recherche du polymorphisme de la thiopurine méthyltransférase et du dosage des métabolites chez les patients traités par azathioprine
چکیده انگلیسی
Azathioprine is widely used in internal medicine and frequently implicated in occurrence of adverse events. Among these adverse events the bone marrow suppression, a dose-related one, is the most serious because of is potential morbidity and mortality. Severe myelosuppression, associated with abnormal AZA metabolism, is linked to the thiopurine methyltransferase (TPMT) genetic polymorphism that results in a high variability of its activity with 89% of patients with a normal activity, 11% with an intermediate activity, and 0.3% with very low activity leading to a very high risk of bonne marrow suppression. TPMT status can be assessed prior to AZA treatment by measuring enzyme activity or genotyping techniques to identify patients for which the standard dose is not advisable. Furthermore, azathioprine metabolites monitoring is helpful for the follow up of patients, especially in therapeutic failure, to distinguish non-compliant patients from under-dosed, “shunters” or resistant patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: La Revue de Médecine Interne - Volume 39, Issue 6, June 2018, Pages 421-426
نویسندگان
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