کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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868376 | 909807 | 2009 | 4 صفحه PDF | دانلود رایگان |
This study presents a new method for the highly selective recognition of chiral mandelic acid (MA) using l-phenylalanine (l-Phe) as the selector. The proposed method is based on quartz crystal microbalance (QCM) detection, integrated with a vapor diffused molecular assembly (VDMA) reaction technique. The construction of the l-Phe-modified QCM sensor involved a two-step assembly procedure. The chiral recognizability of l- and d-MA on the l-Phe-modified surface was then examined using the VDMA method and QCM. The chiral discrimination factor between l- and d-MA detected by QCM, αl-MA/d-MA, was found to be about 8. The VDMA selective sensing of l-MA on the l-Phe-modified surface was also confirmed by the contact angle measurements. The l-Phe-modified QCM sensor showed good stability and reusability. The present chiral recognition results suggest that l-phe is an excellent resolving agent for the resolution of chiral mandelic acid.
Journal: Biosensors and Bioelectronics - Volume 24, Issue 9, 15 May 2009, Pages 2931–2934