کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8683817 | 1579814 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of the anticonvulsant effect of swim stress by agmatine
ترجمه فارسی عنوان
مدولاسیون اثرات ضد انعقاد استرس شنا توسط آگماتین
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Agmatine is an endogenous l-arginine metabolite with neuroprotective effects in the stress-response system. It exerts anticonvulsant effects against several seizure paradigms. Swim stress induces an anticonvulsant effect by activation of endogenous antiseizure mechanisms. In this study, we investigated the interaction of agmatine with the anticonvulsant effect of swim stress in mice on pentylenetetrazole (PTZ)-induced seizure threshold. Then we studied the involvement of nitric oxide (NO) pathway and endogenous opioid system in that interaction. Swim stress induced an anticonvulsant effect on PTZ seizures which was opioid-independent in shorter than 1-min swim durations and opioid-dependent with longer swims, as it was completely reversed by pretreatment with naltrexone (NTX) (10Â mg/kg), an opioid receptor antagonist. Agmatine significantly enhanced the anticonvulsant effect of opioid-independent shorter swim stress, in which a combination of subthreshold swim stress duration (45Â s) and subeffective dose of agmatine (1Â mg/kg) revealed a significantly higher seizure threshold compared with either one. This effect was significantly reversed by NO synthase inhibitor NG-nitro-l-arginine (L-NAME (NÏ-Nitro-L-arginine methyl ester), 5Â mg/kg), suggesting an NO-dependent mechanism, and was unaffected by NTX (10Â mg/kg), proving little role for endogenous opioids in the interaction. Our data suggest that pretreatment of animals with agmatine acts additively with short swim stress to exert anticonvulsant responses, possibly by mediating NO pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 78, January 2018, Pages 142-148
Journal: Epilepsy & Behavior - Volume 78, January 2018, Pages 142-148
نویسندگان
Taraneh Bahremand, Pooya Payandemehr, Kiarash Riazi, Ali Reza Noorian, Borna Payandemehr, Mohammad Sharifzadeh, Ahmad Reza Dehpour,