Human abuse potential of brivaracetam in healthy recreational central nervous system depressant users

This study in healthy recreational CNS depressant users showed that single doses of brivaracetam 50 mg (therapeutic single dose) had lower sedative, positive, and negative drug effects than alprazolam, while brivaracetam 200 and 1000 mg (supratherapeutic single doses) were more similar to alprazolam. The subjective profile of brivaracetam appeared to be similar to that of levetiracetam, but further evaluation using a range of levetiracetam doses would be needed to confirm similar abuse potential.