Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis

► Lafora disease ubiquitin ligase malin regulates neuronatin level and neuronatin-induced glycogen synthesis. ► Neuronatin level is increased in the skin biopsy sample of Lafora disease patients. ► Neuronatin might be implicated in the Lafora body formation or other aspect of Lafora disease pathogenesis.