کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8687724 | 1580949 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Connectivity derived thalamic segmentation in deep brain stimulation for tremor
ترجمه فارسی عنوان
اتصال از طریق تقسیم بندی تالامیک در تحریک مغزی عمیق برای لرزش ایجاد شده است
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کلمات کلیدی
MMSMNIMPTPMPRAGEVBMDWIVTASTNHFSDRTSNRFOVUPDRSFSLPMCDICOMTFCEimplantable pulse generatorGLMVIMFMRIB's Linear Image Registration ToolPFCFMRIBFNIRTSARTMSDBS1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineIPG - GPALEDD - LINKBrain extraction tool - ابزار استخراج مغزConnectivity - اتصالthreshold-free cluster enhancement - افزایش خوشه ای آستانه ایstandard deviation - انحراف معیارcon - باParkinson's disease - بیماری پارکینسونdeep brain stimulation - تحریک عمقی مغزhigh frequency stimulation - تحریک فرکانس بالاTranscranial magnetic stimulation - تحریک مغناطیسی مغزtremor - ترمور یا لرزشDiffusion weighted imaging - تصویر برداری با وزن مخصوصhigh angular resolution diffusion imaging - تصویربرداری با وضوح بالا زاویه ایdigital imaging and communications in medicine - تصویربرداری دیجیتال و ارتباطات در پزشکیstandard error - خطای استانداردSMA - دبیرستانdegrees of freedom - درجه آزادیBET - شرطMagnetization-prepared rapid gradient-echo - شیب سریع شبیه ساز مغناطیسیFLIRT - طلوعconfidence interval - فاصله اطمینانprefrontal cortex - قشر prefrontalprimary motor cortex - قشر حرکتی اولیهprimary sensory cortex - قشر حسی اولیهPremotor cortex - قمر premotorGeneral linear model - مدل خطی کلیUnified Parkinson's Disease Rating Scale - مقیاس درجه بندی بیماری بیماری پارکینسون متحدsupplementary motor area - منطقه موتور تکمیلیVoxel based morphometry - مورفومتری مبتنی بر وکسلMontreal Neurological Institute - موسسه عصبی مونترالField of view - میدان دیدspecific absorption rate - نرخ جذب خاصSignal-to-noise ratio - نسبت سیگنال به نویزHARDI - هاردیventrolateral nucleus - هسته ventrolateralDentate nucleus - هسته دندانه دارSubthalamic nucleus - هسته ی زیرهالامیکPosterior commissure - کمربند عقبanterior commissure - کمربند قدامی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The ventral intermediate nucleus (VIM) of the thalamus is an established surgical target for stereotactic ablation and deep brain stimulation (DBS) in the treatment of tremor in Parkinson's disease (PD) and essential tremor (ET). It is centrally placed on a cerebello-thalamo-cortical network connecting the primary motor cortex, to the dentate nucleus of the contralateral cerebellum through the dentato-rubro-thalamic tract (DRT). The VIM is not readily visible on conventional MR imaging, so identifying the surgical target traditionally involved indirect targeting that relies on atlas-defined coordinates. Unfortunately, this approach does not fully account for individual variability and requires surgery to be performed with the patient awake to allow for intraoperative targeting confirmation. The aim of this study is to identify the VIM and the DRT using probabilistic tractography in patients that will undergo thalamic DBS for tremor. Four male patients with tremor dominant PD and five patients (three female) with ET underwent high angular resolution diffusion imaging (HARDI) (128 diffusion directions, 1.5â¯mm isotropic voxels and b valueâ¯=â¯1500) preoperatively. Patients received VIM-DBS using an MR image guided and MR image verified approach with indirect targeting. Postoperatively, using parallel Graphical Processing Unit (GPU) processing, thalamic areas with the highest diffusion connectivity to the primary motor area (M1), supplementary motor area (SMA), primary sensory area (S1) and contralateral dentate nucleus were identified. Additionally, volume of tissue activation (VTA) corresponding to active DBS contacts were modelled. Response to treatment was defined as 40% reduction in the total Fahn-Tolosa-Martin Tremor Rating Score (FTMTRS) with DBS-ON, one year from surgery. Three out of nine patients had a suboptimal, long-term response to treatment. The segmented thalamic areas corresponded well to anatomically known counterparts in the ventrolateral (VL) and ventroposterior (VP) thalamus. The dentate-thalamic area, lay within the M1-thalamic area in a ventral and lateral location. Streamlines corresponding to the DRT connected M1 to the contralateral dentate nucleus via the dentate-thalamic area, clearly crossing the midline in the mesencephalon. Good response was seen when the active contact VTA was in the thalamic area with highest connectivity to the contralateral dentate nucleus. Non-responders had active contact VTAs outside the dentate-thalamic area. We conclude that probabilistic tractography techniques can be used to segment the VL and VP thalamus based on cortical and cerebellar connectivity. The thalamic area, best representing the VIM, is connected to the contralateral dentate cerebellar nucleus. Connectivity based segmentation of the VIM can be achieved in individual patients in a clinically feasible timescale, using HARDI and high performance computing with parallel GPU processing. This same technique can map out the DRT tract with clear mesencephalic crossing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 18, 2018, Pages 130-142
Journal: NeuroImage: Clinical - Volume 18, 2018, Pages 130-142
نویسندگان
Harith Akram, Viswas Dayal, Philipp Mahlknecht, Dejan Georgiev, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Marjan Jahanshahi, John Ashburner, Tim Behrens, Marwan Hariz, Ludvic Zrinzo,