کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
868774 909813 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GMR biosensor arrays: Correction techniques for reproducibility and enhanced sensitivity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
GMR biosensor arrays: Correction techniques for reproducibility and enhanced sensitivity
چکیده انگلیسی

Giant magnetoresistive biosensors possess great potential in biomedical applications for quantitatively detecting magnetically tagged biomolecules. Magnetic sensing does not suffer from the high background levels found in optical sensing modalities such as the enzyme linked immunosorbent assay translating into a technology with higher sensitivity. However, to reveal the full potential of these sensors and compensate for non-idealities such as temperature dependence, digital correction and calibration techniques are not only useful but imperative. Using these calibration techniques to correct for process variations and dynamic changes in the sensing environment (such as temperature and magnetic field), we are able to obtain extremely sensitive and, more importantly, reproducible results for quantifiable biomolecular reorganization. The reproducibility of the system was improved by over 3× using digital correction techniques and the sensors are made temperature independent by using a novel background correction technique.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 25, Issue 9, 15 May 2010, Pages 2177–2181
نویسندگان
, , , , ,