کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8688998 | 1580955 | 2016 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure
ترجمه فارسی عنوان
بیماری ماده سفید در دوران میانسالی، قابل انتقال، مرتبط با فشار خون بالا است و برخی از تاثیرات ژنتیکی را با فشار خون سیستولیک به اشتراک می گذارد
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کلمات کلیدی
HTNICVSBPDBPHDLhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاApoe - آپوapolipoprotein E - آپولیپوپروتئین EMRI - امآرآی یا تصویرسازی تشدید مغناطیسیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیHypertension - فشار خون بالاdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکBlood pressure - فشارخونLDL - لیپوپروتئین کم چگالی(کلسترول بد)white matter - ماده سفیدBrain - مغزHeritability - وراثت پذیریC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی low - کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
White matter disease in the brain increases with age and cardiovascular disease, emerging in midlife, and these associations may be influenced by both genetic and environmental factors. We examined the frequency, distribution, and heritability of abnormal white matter and its association with hypertension in 395 middle-aged male twins (61.9 ± 2.6 years) from the Vietnam Era Twin Study of Aging, 67% of whom were hypertensive. A multi-channel segmentation approach estimated abnormal regions within the white matter. Using multivariable regression models, we characterized the frequency distribution of abnormal white matter in midlife and investigated associations with hypertension and Apolipoprotein E-ε4 status and the impact of duration and control of hypertension. Then, using the classical twin design, we estimated abnormal white matter heritability and the extent of shared genetic overlap with blood pressure. Abnormal white matter was predominantly located in periventricular and deep parietal and frontal regions; associated with age (t = 1.9, p = 0.05) and hypertension (t = 2.9, p = 0.004), but not Apolipoprotein ε4 status; and was greater in those with uncontrolled hypertension relative to controlled (t = 3.0, p = 0.003) and normotensive (t = 4.0, p = 0.0001) groups, suggesting that abnormal white matter may reflect currently active cerebrovascular effects. Abnormal white matter was highly heritable (a2 = 0.81) and shared some genetic influences with systolic blood pressure (rA = 0.26), although there was evidence for distinct genetic contributions and unique environmental influences. Future longitudinal research will shed light on factors impacting white matter disease presentation, progression, and potential recovery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 12, February 2016, Pages 737-745
Journal: NeuroImage: Clinical - Volume 12, February 2016, Pages 737-745
نویسندگان
Christine PhD, Linda K. PhD, Randy MS, Matthew S. PhD, Wai-Ying Wendy Yau, Carol E. PhD, Michael J. PhD, Lisa T. PhD, Michael C. PhD, Hong PhD, Ruth E. PhD, William S. PhD,