کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8720649 | 1589308 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microbiome, pattern recognition receptor function in health and inflammation
ترجمه فارسی عنوان
میکروبیوم، عملکرد گیرنده شناخت الگوی در سلامت و التهاب
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کلمات کلیدی
ایمنی فزاینده، میکروبیوتا، گیرنده های تشخیص الگو، پاتوژن وابسته به مولکول های وابسته، نقص ژنتیکی، دیس بیوسی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی
The innate immune system plays an important role in shaping the microbiota into configurations that are tolerated and beneficial to the host, thereby playing a crucial role in human health. Innate immunity is based on the fundamental principle that Pattern Recognition Receptors (PRRs) recognise pathogen associated molecular patterns as non-self-entities and trigger intracellular signalling pathways that lead to the induction of numerous cytokines and chemokines that help maintain host resistance to infections. Dysregulation of this interaction has been identified as the core defect that leads to chronic intestinal inflammation allowing certain microbiota to be harmful to host health. This dysbiosis of the microbiome is found associated with numerous chronic diseases. A logical explanation would be that genetic defects in the recognition and response pathways that the host uses to identify these microbial pathogens could lead to altered microbial colonisation or mis-recognition of normal bacteria leading to diseases. The interaction between pattern recognition receptors, microbial traits and human health with respect to the gut are now rapidly resolved and will be the subject of this review.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Gastroenterology - Volume 31, Issue 6, December 2017, Pages 683-691
Journal: Best Practice & Research Clinical Gastroenterology - Volume 31, Issue 6, December 2017, Pages 683-691
نویسندگان
David Fawkner-Corbett, Alison Simmons, Kaushal Parikh,