کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8721286 1589399 2018 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A young girl with severe cerebral fungal infection due to card 9 deficiency
ترجمه فارسی عنوان
یک دختر جوان با عفونت قارچی شدید مغزی به علت کمبود کارت 9
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Pattern recognition receptors (PRRs), receptors of the innate immune system, are important in interaction with pathogens. Caspase Recruitment Domain-containing protein 9 (CARD9), a member of PRRs, is an intracellular adaptor protein important in fungal defense. CARD9 deficiency causes a rare primary immunodeficiency (PID) characterized by superficial and deep fungal infections. We report a 17 year-old female with a homozygous nonsense mutation in CARD9, who presented with severe cerebral fungal infection of the central nervous system. She was also found to have an heterozygous NLRP12 mutation, which may have had add-on effect on the severity of the infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 191, June 2018, Pages 21-26
نویسندگان
, , , , , , , , ,