Progressive severe B cell and NK cell deficiency with T cell senescence in adult CD40L deficiency

- CD40 Ligand deficiency may result in severe B and NK loss over time.
- T cell senescence is a novel finding in adult CD40 Ligand deficiency.
- Long term follow-up of CD40 Ligand deficiency may reveal novel immunological findings.
- CD40 Ligand deficient patients not undergoing HSCT should be closely monitored.