کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8721383 | 1589402 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype
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کلمات کلیدی
mAbPBMCIRBTregT1DTh1 and Th2Monoclonal antibody - آنتی بادی مونوکلونالEffector memory - حافظه EffectorCentral memory - حافظه مرکزیType 1 diabetes - دیابت نوع۱T cell subsets - زیر مجموعه های سلول Tperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیCytokines - سیتوکین هاinstitutional review board - هیئت بررسی نظارتChemokine receptors - گیرنده های شیمیایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
CD4+ T cells that co-express CD25 and CD127 (CD25+Â CD127+) make up around 20% of all circulating CD4+ memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25+Â CD127hi cells. We show that they are a mix of Th1 and Th2 cells however, they have a significantly higher relative frequency of pre-committed and committed Th2 cells, and secrete significantly higher levels of Th2-type cytokines than CD25â memory T cells. Further, these cells are neither exhausted nor senescent and proliferate to the same extent as CD25â memory cells. Thus, CD25+Â CD127hi cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 188, March 2018, Pages 103-112
Journal: Clinical Immunology - Volume 188, March 2018, Pages 103-112
نویسندگان
Aditi Narsale, Rosita Moya, Joanna Davida Davies,