کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8721402 | 1589403 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The cell-surface glycoprotein CD52 is widely expressed in lymphocytes. CD4+Â CD52hi T cells are functioning suppressor CD4+Â T cells. We investigated the role of the immune regulation of CD4+Â CD52 T cells in systemic lupus erythematosus (SLE). CD4+Â CD52lo T cells were increased in SLE patients, in positive correlation with SLEDAI, anti-ds-DNA antibody, and IgG concentration. Circulating follicular helper-like T cells (Tfh-like cells) were also increased in SLE, in positive correlation with CD4+Â CD52lo T cells. Chemokine receptor 8 (CCR8) expression in CD4+Â CD52lo T cells was increased. In vitro experiments using CD4 T cells of SLE patients showed that thymus and activation-regulated chemokine (TARC), a ligand of CCR8, contributed to the development of CD4+Â CD52hi T cells into CD4+Â CD52lo T cells. Our findings suggest that CD4Â +Â CD52lo T-cell upregulation is involved in the production of pathogens by autoantibodies, and TARC may contribute to the development of SLE through an aberrant induction of CD4+Â CD52lo T cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 187, February 2018, Pages 50-57
Journal: Clinical Immunology - Volume 187, February 2018, Pages 50-57
نویسندگان
Masataka Umeda, Tomohiro Koga, Kunihiro Ichinose, Takashi Igawa, Tomohito Sato, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Ayako Nishino, Yoshiro Horai, Yasuko Hirai, Shin-ya Kawashiri, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai,