کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8732843 | 1590549 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Papel da via de sinalização do HIFâ1α na osteoartrite: revisão sistemática
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب سالمندان و علم پیری شناسی
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![عکس صفحه اول مقاله: Papel da via de sinalização do HIFâ1α na osteoartrite: revisão sistemática Papel da via de sinalização do HIFâ1α na osteoartrite: revisão sistemática](/preview/png/8732843.png)
چکیده انگلیسی
Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIFâ1α). HIFâ1α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIFâ1α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIFâ1α in the scientific literature in the last years, we focused the present review on the potential role of HIFâ1α signaling pathway in OA development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Brasileira de Reumatologia - Volume 57, Issue 2, MarchâApril 2017, Pages 162-173
Journal: Revista Brasileira de Reumatologia - Volume 57, Issue 2, MarchâApril 2017, Pages 162-173
نویسندگان
Javier FernándezâTorres, Gabriela Angélica MartÃnezâNava, MarÃa Concepción GutiérrezâRuÃz, Luis Enrique GomezâQuiroz, Marwin Gutiérrez,