کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8733606 1590691 2018 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology
ترجمه فارسی عنوان
تغییرات ژنتیکی از مرزهای خطوط متمایز هماتوپوئیت و تومورهای جامد عبور می کنند: چالش های تشخیصی در دوران توالی سلول های خونی در هموگلوبین
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Owing to the introduction of next-generation sequencing (NGS) new challenges for diagnostic algorithms and the interpretation of the results for therapeutic decision making in hemato-oncology have arisen. Recurrent somatic mutations crossing the borders between different hematological entities and solid neoplasms have been detected. In analogy to mutant TP53, the same mutation type may occur in myeloid, B- or T-lymphatic malignancies or solid neoplasms. At the same time, a certain mutation can show different prognostic outcomes in different entities and co-existence of certain mutations may change the prognostic relevance. These insights may spark the investigation of targeted therapies with the same substances across different disease entities. This review article summarizes mutations that can emerge in different hematologic and solid malignancies and summarizes other obstacles in the era of modern molecular diagnostics, such as the phenomenon of “clonal hematopoiesis of indeterminate potential” being difficult to interpret in the individual patient.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 126, June 2018, Pages 64-79
نویسندگان
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