کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8733687 1590694 2018 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
The SWI/SNF complex subunit genes: Their functions, variations, and links to risk and survival outcomes in human cancers
چکیده انگلیسی
SWI/SNF is a multiprotein complex essential for regulation of eukaryotic gene expression. In this article, we review the function and characteristics of this complex and its subunits in cancer-related phenotypes. We also present and discuss the publically available survival analysis data for TCGA patient cohorts, revealing novel relationships between the expression levels of the SWI/SNF subunit genes and patient survival times in several cancers. Overall, multiple lines of research point to a wide-spread role for the SWI/SNF complex genes in human cancer susceptibility and patient survival times. Examples include the mutations in ARID1A with cancer-driving effects, associations of tumor SWI/SNF gene expression levels and patient survival times, and two BRM promoter region polymorphisms linked to risk or patient outcomes in multiple human cancers. These findings should motivate comprehensive studies in order to fully dissect these relationships and verify the potential clinical utility of the SWI/SNF genes in controlling cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 123, March 2018, Pages 114-131
نویسندگان
, ,