کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8733698 1590695 2018 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review
ترجمه فارسی عنوان
اثر محافظتی کورکومین بر سمیت و مقاومت ناشی از دوکسوروبیسین: بررسی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic approaches. Despite effective in the treatment of numerous malignancies, some clinicians have voiced concern that DOX has the potential to cause debilitating consequences in organ tissues, especially the heart. The mechanisms of toxicity and resistance are respectively related to induction of reactive oxygen species (ROS) and up-regulation of ATP-binding cassette (ABC) transporter. Curcumin (CUR) with several biological and pharmacological properties is expected to restore DOX-mediated impairments to tissues. This review is intended to address the current knowledge on DOX adverse effects and CUR protective actions in the heart, kidneys, liver, brain, and reproductive organs. Coadministration of CUR and DOX is capable of ameliorating DOX toxicity pertained to antioxidant, apoptosis, autophagy, and mitochondrial permeability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 122, February 2018, Pages 30-51
نویسندگان
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