کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8733733 | 1590696 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A review of the literature on the relationships between genetic polymorphisms and chemotherapy-induced nausea and vomiting
ترجمه فارسی عنوان
بررسی ادبیات مربوط به ارتباط بین پلی مورفیسم ژنتیک و تهوع و استفراغ ناشی از شیمیدرمانی
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کلمات کلیدی
حالت تهوع، استفراغ، سروتونین، متابولیسم مواد مخدر، حمل و نقل مواد مخدر، ضد عفونی کننده
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
چکیده انگلیسی
Despite current advances in antiemetic treatments, between 30% to and 60% of oncology patients experience chemotherapy-induced nausea (CIN) and 13% to 33% report chemotherapy-induced vomiting (CIV). Inter-individual differences are observed in the occurrence and severity of chemotherapy-induced nausea and vomiting (CINV). This review summarizes and critiques studies on associations between occurrence and severity of CINV and polymorphisms in serotonin receptor, drug metabolism, and drug transport pathway genes. Sixteen studies evaluated the associations between the occurrence and/or severity of CINV and single nucleotide polymorphisms (SNPs). Across these studies, three SNPs in 5-hydroxytryptamine receptor (5-HT3R) genes, two alleles of the cytochrome P450 family 2 subfamily D member 6 (CYP2D6) gene, and three SNPs in ATP binding cassette subfamily B member 1 (ABCB1) gene were associated with the occurrence and severity of CINV. Given the limited number of polymorphisms evaluated, additional research is warranted to identify new mechanisms to develop more targeted therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 121, January 2018, Pages 51-61
Journal: Critical Reviews in Oncology/Hematology - Volume 121, January 2018, Pages 51-61
نویسندگان
Komal P. Singh, Anand A. Dhruva, Elena Flowers, Kord M. Kober, Christine Miaskowski,