کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8735040 1591018 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
What is the evidence for the role of therapeutic apheresis in the management of complement-associated thrombotic microangiopathies?
ترجمه فارسی عنوان
شواهد موجود در مورد نقش فنیل های درمانی در مدیریت میکروآنژیوپات های ترومبوتیک همراه با مکمل چیست؟
کلمات کلیدی
میکروآنژیوپاتی ترومبوتیک، سیستم مکمل جایگزین، میکروآنژیوپاتی ترومبوتیک تکمیلی، افسردگی درمانی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Thrombotic microangiopathies (TMAs) are disorders characterized by endothelial cell activation, microangiopathic hemolytic anemia, thrombocytopenia and organ failure of variable intensity. The pathophysiology of various types of TMAs have become an interesting field of study. Alternative complement system activation plays an important role in several pathophysiological conditions. Complement activation is also described in an increasing number of TMAs. Inherited defects in complement regulatory genes and acquired autoantibodies against complement regulatory proteins have been described. Atypical hemolytic uremic synrome (HUS) is caused by uncontrolled activation of the alternative complement system, now called complement-mediated TMAs. Recently, application of a monoclonal antibody that specifically binds to C5 became available to treat patients with complement-mediated TMAs. Eculizumab is a humanized monoclonal antibody that blocks complement C5 activation. Empiric therapeutic apheresis is also recommended in all forms of complement-mediated TMAs. The justification for therapeutic apheresis use in all forms of complement-mediated TMAs is that it can effectively remove the autoantibodies or mutated circulating complement regulators while replacing absent or defective complement regulators. Currently, therapeutic apheresis and eculizumab are the available treatment options for complement-mediated TMAs. In this paper, we review the evidence for the role of therapeutic apheresis in the management of complement-associated TMAs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transfusion and Apheresis Science - Volume 57, Issue 1, February 2018, Pages 31-34
نویسندگان
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