کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8736482 | 1591141 | 2018 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis
ترجمه فارسی عنوان
درمان ترکیبی برای درمان بیماری های پیچیده: نقش میکروبیوتومی روده در مولتیپل اسکلروزیس
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کلمات کلیدی
AHRIELsEDSSHCsEAEDMTCISDMFexperimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینgerm-free - بدون میکروبdisease-modifying treatment - درمان تغییر دهنده بیماریCNS - دستگاه عصبی مرکزیdimethyl fumarate - دی متیل فوماراتBBB - سد خونی مغزیDendritic cell - سلول دندریتیکclinically isolated syndrome - سندرم انزال بالینیcentral nervous system - سیستم عصبی مرکزیintraepithelial lymphocytes - لنفوسیت های داخل اپیتلیالBlood-brain barrier - مانع خون مغزیExpanded Disability Status Scale - مقیاس وضعیت ناتوانی گسترش یافتهhealthy controls - کنترل های سالمglatiramer acetate - گتییمر استاتaryl hydrocarbon receptor - گیرنده آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
The commensal microbiota has emerged as an environmental risk factor for multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE) models have shown that the commensal microbiota is an essential player in triggering autoimmune demyelination. Likewise, the commensal microbiota modulates the host immune system, alters the integrity and function of biological barriers and has a direct effect on several types of central nervous system (CNS)-resident cells. Moreover, a characteristic gut dysbiosis has been recognized as a consistent feature during the clinical course of MS, and the MS-related microbiota is gradually being elucidated. This review highlights animal studies in which commensal microbiota modulation was tested in EAE, as well as the mechanisms of action and influence of the commensal microbiota not only in the local milieu but also in the innate and adaptive immune system and the CNS. Regarding human research, this review focuses on studies that show how the commensal microbiota might act as a pathogenic environmental risk factor by directing immune responses towards characteristic pathogenic profiles of MS. We speculate how specific microbiome signatures could be obtained and used as potential pathogenic events and biomarkers for the clinical course of MS. Finally, we review recently published and ongoing clinical trials in MS patients regarding the immunomodulatory properties exerted by some microorganisms. Because MS is a complex disease with a large variety of associated environmental risk factors, we suggest that current treatments combined with strategies that modulate the commensal microbiota would constitute a broader immunotherapeutic approach and improve the clinical outcome for MS patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 17, Issue 2, February 2018, Pages 165-174
Journal: Autoimmunity Reviews - Volume 17, Issue 2, February 2018, Pages 165-174
نویسندگان
Laura Calvo-Barreiro, Herena Eixarch, Xavier Montalban, Carmen Espejo,