کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8737675 | 1591370 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Collection and storage of HLA NGS genotyping data for the 17th International HLA and Immunogenetics Workshop
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کلمات کلیدی
SBTSFTPIUPACIMGTGFEHMLIPDSSPGenotype ListKirSSOsequence-specific primingcomma-separated valuesNGSrSCASequence-SpecificCSVHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیInternational Union of Pure and Applied Chemistry - اتحادیه ی بین المللی شیمی محض و کاربردیXML - اکسامالImmunogenetics - ایمونوگنیکDatabase - بانک اطلاعاتی، دادِگان یا دِیتابِیسsequence-based typing - تایپ مبتنی بر دنبالهReference Strand Conformation Analysis - تجزیه و تحلیل سازگاری رشته مرجعNext generation sequencing - توالی نسل بعدیextensible markup language - زبان نشانه گذاری توسعه پذیرPrincipal investigator - محقق اصلیData management - مدیریت دادهWorkshop - کارگاه آموزشیkiller-cell immunoglobulin-like receptor - گیرنده ایمونوگلوبولین مشابه سلول قاچاق
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
For over 50â¯years, the International HLA and Immunogenetics Workshops (IHIW) have advanced the fields of histocompatibility and immunogenetics (H&I) via community sharing of technology, experience and reagents, and the establishment of ongoing collaborative projects. Held in the fall of 2017, the 17th IHIW focused on the application of next generation sequencing (NGS) technologies for clinical and research goals in the H&I fields. NGS technologies have the potential to allow dramatic insights and advances in these fields, but the scope and sheer quantity of data associated with NGS raise challenges for their analysis, collection, exchange and storage. The 17th IHIW adopted a centralized approach to these issues, and we developed the tools, services and systems to create an effective system for capturing and managing these NGS data. We worked with NGS platform and software developers to define a set of distinct but equivalent NGS typing reports that record NGS data in a uniform fashion. The 17th IHIW database applied our standards, tools and services to collect, validate and store those structured, multi-platform data in an automated fashion. We have created community resources to enable exploration of the vast store of curated sequence and allele-name data in the IPD-IMGT/HLA Database, with the goal of creating a long-term community resource that integrates these curated data with new NGS sequence and polymorphism data, for advanced analyses and applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 79, Issue 2, February 2018, Pages 77-86
Journal: Human Immunology - Volume 79, Issue 2, February 2018, Pages 77-86
نویسندگان
Chia-Jung Chang, Kazutoyo Osoegawa, Robert P. Milius, Martin Maiers, Wenzhong Xiao, Marcelo Fernandez-ViÅa, Steven J. Mack,