کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8744467 | 1592746 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
CC chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Î32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans. Patients with positive serology for Toxoplasma gondii were analyzed and grouped as 'with ocular toxoplasmosis' (G1: n = 160) or 'without ocular toxoplasmosis' (G2: n = 160). A control group (G3) consisted of 160 individuals with negative serology. The characterization of the CCR5Î32 and CCR5 59029 A/G polymorphisms was by PCR and by PCR-RFLP, respectively. The difference between the groups with respect to the mean age (G1: mean age: 47.3, SD ± 19.3, median: 46 [range: 18-95]; G2: mean age: 61.3, SD ± 13.7, median: 61 [range: 21-87]; G3: mean age: 38.8, SD ± 17.9, median: 34 [range: 18-80]) was statistically significant (G1 vs.G2: p-value <0.0001; t = 7.21; DF = 318; G1 vs.G3: p-value <0.0001; t = 4.32; DF = 318; G2 vs. G3: p-value <0.0001; t = 9.62; DF = 318). The Nagelkerke r2 value was 0.040. There were statistically significant differences for the CCR5/CCR5 (p-value = 0.008; OR = 0.261), AA (p-value = 0.007; OR = 2.974) and AG genotypes (p-value = 0.018; OR = 2.447) between G1 and G2. Individuals with the CCR5/CCR5 genotype and simultaneously the CCR5-59029 AA or AG genotypes have a greater risk of developing ocular toxoplasmosis (4% greater), which may be associated with a strong and persistent inflammatory response in ocular tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 178, February 2018, Pages 276-280
Journal: Acta Tropica - Volume 178, February 2018, Pages 276-280
نویسندگان
Geraldo M. de Faria Junior, Christiane M. Ayo, Amanda P. de Oliveira, Alessandro G. Lopes, Fábio B. Frederico, Aparecida P. Silveira-Carvalho, Mariana Previato, Amanda P. Barbosa, Fernando H.A. Murata, Gildásio Castello de Almeida Junior,