کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8744496 1592811 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of humoral neutralizing antibody response in rabbits, guinea pigs, and cattle vaccinated with epsilon and beta toxoids from Clostridium perfringens and C. botulinum types C and D toxoids
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Comparison of humoral neutralizing antibody response in rabbits, guinea pigs, and cattle vaccinated with epsilon and beta toxoids from Clostridium perfringens and C. botulinum types C and D toxoids
چکیده انگلیسی
Rabbits and guinea pigs are used in the official control and validation of clostridial vaccines, but it is unknown whether the antitoxin titers obtained in these animals corroborate with the humoral response in bovine. The objective of the study was to compare the humoral antibody response of guinea pig and rabbits to those obtained in cattle vaccinated with a commercial vaccine containing Clostridium perfringens epsilon and beta, and Clostridium botulinum types C and D toxoids. This study revealed the same level of humoral response in rabbits and cattle for all four toxoids tested, including C. botulinum types C and D toxoids. In contrast, the titers of neutralizing antibodies against C. botulinum type C toxin in guinea pigs differed from those obtained in cattle. Thus, the present work suggests that the potency test for C. botulinum types C in rabbits agrees more with the humoral response in cattle than the potency test in guinea pigs, thereby making it possible to use only rabbits as models in the official control and validations of clostridial vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Anaerobe - Volume 54, December 2018, Pages 19-22
نویسندگان
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