کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8745041 | 1593024 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell
ترجمه فارسی عنوان
یکپارچه سازی شبکه های ارتباطی ژنتیکی و پروتئین-پروتئین، یک نمودار سیم کشی کاربردی یک سلول را نشان می دهد
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
چکیده انگلیسی
Systematic experimental approaches have led to construction of comprehensive genetic and protein-protein interaction networks for the budding yeast, Saccharomyces cerevisiae. Genetic interactions capture functional relationships between genes using phenotypic readouts, while protein-protein interactions identify physical connections between gene products. These complementary, and largely non-overlapping, networks provide a global view of the functional architecture of a cell, revealing general organizing principles, many of which appear to be evolutionarily conserved. Here, we focus on insights derived from the integration of large-scale genetic and protein-protein interaction networks, highlighting principles that apply to both unicellular and more complex systems, including human cells. Network integration reveals fundamental connections involving key functional modules of eukaryotic cells, defining a core network of cellular function, which could be elaborated to explore cell-type specificity in metazoans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Microbiology - Volume 45, October 2018, Pages 170-179
Journal: Current Opinion in Microbiology - Volume 45, October 2018, Pages 170-179
نویسندگان
Benjamin VanderSluis, Michael Costanzo, Maximilian Billmann, Henry N. Ward, Chad L. Myers, Brenda J. Andrews, Charles Boone,