کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8749390 | 1593668 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Occurrence of APOBEC3G variations in West Indian HIV patients
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
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چکیده انگلیسی
The genetic variations in APOBEC3G gene are correlated with HIV disease progression. These variations differ in different ethnic groups. The prevalence of APOBEC3G (-90C/G, â571G/C) variations have not been studied in Indian population. Hence, we assessed the occurrence of APOBEC3G polymorphisms in HIV patients and its association with acquisition of HIV and disease progression. Polymorphisms in APOBEC3G were genotyped in a total of 153 HIV patients, naïve to ARV and 156 healthy controls by PCR-RFLP method. In single locus model, the frequency of distribution of APOBEC3G â90CG, â571Â GC genotypes were higher in HIV patients as compared to healthy controls (57.5% vs. 50.0%, ORÂ =Â 1.22; 17.0% vs. 12.8%, ORÂ =Â 1.39). In double locus model, the dominant â571Â GCÂ +Â CC genotype was distributed at a much higher frequency in HIV patients as compared to healthy controls (18.3% vs. 14.1%, ORÂ =Â 1.50). The frequency of APOBEC3G â571CC and CCÂ +Â GC genotypes were higher in early HIV disease stage as compared to healthy controls (23.9% vs. 12.8%, ORÂ =Â 2.23, PÂ =Â 0.08; 28.3% vs. 14.1%, ORÂ =Â 2.40, PÂ =Â 0.04). APOBEC3G-571Â GC and GCÂ +Â CC genotypes were more prevalent in HIV patients consuming tobacco and alcohol as compared to non-users (22.7% vs. 15.3%, ORÂ =Â 1.71, PÂ =Â 0.56; 27.3% vs. 16.5%, ORÂ =Â 1.90, PÂ =Â 0.39 and 31.6% vs. 13.6%, ORÂ =Â 2.31, PÂ =Â 0.08; 36.8% vs14.8%, ORÂ =Â 2.49, PÂ =Â 0.04, respectively). In conclusion, APOBEC3G-571G/C polymorphism was associated with the early stage of HIV infection and could potentially influence HIV disease progression in alcohol users. The distribution of APOBEC3G polymorphisms and its haplotypes were not significantly different between HIV patients and healthy controls.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 121, August 2018, Pages 325-330
Journal: Microbial Pathogenesis - Volume 121, August 2018, Pages 325-330
نویسندگان
HariOm Singh, R.R. Gangakhedkar,