کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8749545 | 1593671 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of Rab GTPases in HSV-1 infection: Molecular understanding of viral maturation and egress
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of Rab GTPases in HSV-1 infection: Molecular understanding of viral maturation and egress Role of Rab GTPases in HSV-1 infection: Molecular understanding of viral maturation and egress](/preview/png/8749545.png)
چکیده انگلیسی
Most enveloped viruses exploit complex cellular pathways for assembly and egress from the host cell, and the large DNA virus Herpes simplex virus 1 (HSV-1) makes no exception, hijacking several cellular transport pathways for its glycoprotein trafficking and maturation, as well as for viral morphogenesis and egress according to the envelopment, de-envelopment and re-envelopment model. Importantly Rab GTPases, widely distributed master regulators of intracellular membrane trafficking pathways, have recently being tightly implicated in such process. Indeed, siRNA-mediated genetic ablation of specific Rab proteins differently affected HSV-1 production, suggesting a complex role of different Rab proteins in HSV-1 life cycle. In this review, we discuss how different Rabs can regulate HSV-1 assembly/egress and the potential therapeutic applications of such findings for the management of HSV-1 infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 118, May 2018, Pages 146-153
Journal: Microbial Pathogenesis - Volume 118, May 2018, Pages 146-153
نویسندگان
Sohail Raza, Gualtiero Alvisi, Farzana Shahin, Urooj Husain, Masood Rabbani, Tahir Yaqub, Aftab Ahmad Anjum, Ali Ahmad Sheikh, Muhammad Nawaz, Muhammad Asad Ali,