کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8750012 | 1593689 | 2016 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical relevance of Helicobacter pylori virulence factors in Iranian patients with gastrointestinal diseases
ترجمه فارسی عنوان
ارتباط بالینی عوامل ویروسی هلیکو باکتر پیلوری در بیماران ایرانی با بیماری های دستگاه گوارش
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کلمات کلیدی
هلیکوباکتر پیلوری، گاستریت، زخم های گوارشی، سرطان معده، عوامل ویروسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
چکیده انگلیسی
Helicobacter pylori (H. pylori) usually colonizes the gastric mucosa of more than 50% of the human population, causing an infection that may appear in early childhood and can persist for life. H. pylori is suggested as the main cause of peptic ulcer and chronic gastritis. It is also associated with gastric cancer. Its severity and symptoms depend on environmental factors, host susceptibility and bacterial components, which allow H. pylori to switch between commensalism and pathogenicity. H. pylori is genetically highly variable, and the variability which affects H. pylori virulence factors might be useful in identifying the strains with different degrees of pathogenicity. The geographic distribution of distinct H. pylori genotypes is largely unknown and should be established. The prevalence of more pathogenic genotypes in certain areas may have important epidemiological consequences. It also might be associated with the severity of H. pylori related diseases in such regions. Given that Iran is located in the Middle East and Asian populations have revealed high levels of gastric cancer, it is of clinical interest to clarify the potential of H. pylori virulence markers in predicting the associated clinical outcomes. In this review, clinical relevance of adhesion molecules and significant virulence factors of H. pylori in Iranian patients with gastrointestinal diseases are discussed in comparison to other countries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 100, November 2016, Pages 154-162
Journal: Microbial Pathogenesis - Volume 100, November 2016, Pages 154-162
نویسندگان
Nader Bagheri, Fatemeh Azadegan-Dehkordi, Mahmoud Rafieian-Kopaei, Ghorbanali Rahimian, Majid Asadi-Samani, Hedaytollah Shirzad,