کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8751406 | 1594197 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vascular endothelial injury in severe fever with thrombocytopenia syndrome caused by the novel bunyavirus
ترجمه فارسی عنوان
آسیب اندوتلیال عروق در تب شدید با سندرم ترومبوسیتوپنی ناشی از ویروس جدید بونویو
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Severe fever with thrombocytopenia syndrome virus (SFTSV) infection typically causes acute fever, thrombocytopenia and leucopenia, presenting with a high case fatality rate. The pathogenesis of SFTSV infection, however, is not well described. It was hypothesized that endothelial dysfunction might play part in the disease process. In current study, we retrospectively analyzed the clinical manifestations among a large group of confirmed SFTS cases and found evidence of plasma leakage and vascular endothelial injury. Then we established a SFTSV infection cell model and determined the infectivity and stimulation of SFTSV on vascular endothelial cells in vitro. The hyperpermeability of endothelial cells directly induced by SFTSV was confirmed by electrical resistance and dextran diffusion assay. The virus induced alterations of cell junctions and cytoskeleton was also revealed. It's suggested that vascular endothelial cell injury and barrier function damage were induced after SFTSV infection, which is a vital but neglected pathogenesis of SFTS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 520, July 2018, Pages 11-20
Journal: Virology - Volume 520, July 2018, Pages 11-20
نویسندگان
Xiao-Kun Li, Shao-Fei Zhang, Wen Xu, Bo Xing, Qing-Bin Lu, Pan-He Zhang, Hao Li, Li Zhang, Wen-Cong Zhang, Wei-Wei Chen, Wu-Chun Cao, Wei Liu,