کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8751486 | 1594199 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus
ترجمه فارسی عنوان
کاهش سطح دیپپتیدیل پپتیداز محلول در پلاسمای بیماران مبتلا به کروناویروس سندرم تنفسی خاورمیانه
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
چکیده انگلیسی
Dipeptidyl peptidase 4 (DPP4) is a receptor for MERS-CoV. The soluble form of DPP4 (sDPP4) circulates systematically and can competitively inhibit MERS-CoV entry into host cells. Here, we measured the concentration of sDPP4 in the plasma and sputa of 14 MERS-CoV-infected patients of various degrees of disease severity. The concentration of sDPP4 in the plasma of MERS patients (474.76â¯Â±â¯108.06â¯ng/ml) was significantly lower than those of healthy controls (703.42â¯Â±â¯169.96â¯ng/ml), but there were no significant differences among the patient groups. Interestingly, plasma levels of IL-10 and EGF were negatively and positively correlated with sDPP4 concentrations, respectively. The sDPP4 levels in sputa were less than 300â¯ng/ml. Viral infection was inhibited by 50% in the presence of more than 8000â¯ng/ml of sDPP4. Therefore, sDPP4 levels in the plasma of MERS patients are significantly reduced below the threshold needed to exert an antiviral effect against MERS-CoV infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 518, May 2018, Pages 324-327
Journal: Virology - Volume 518, May 2018, Pages 324-327
نویسندگان
Kyung-Soo Inn, Yuri Kim, Abdimadiyeva Aigerim, Uni Park, Eung-Soo Hwang, Myung-Sik Choi, Yeon-Sook Kim, Nam-Hyuk Cho,