کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8751557 | 1594202 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice](/preview/png/8751557.png)
چکیده انگلیسی
Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1-/- hematopoietic cells and Stat1-/- stromal cells, and that the presence of wild-type hematopoietic or stromal cells was sufficient to restore normal development of Stat1-/- B cells. These results suggest that B cells normally restrain norovirus replication in a cell autonomous manner, and that wild-type STAT1 is required to protect B cell development during infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 515, February 2018, Pages 123-133
Journal: Virology - Volume 515, February 2018, Pages 123-133
نویسندگان
Charlie C. Hsu, Stacey M. Meeker, Sabine Escobar, Thea L. Brabb, Jisun Paik, Heon Park, Brian M. Iritani, Lillian Maggio-Price,