کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8765546 | 1597721 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ALA-PDT exerts beneficial effects on chronic venous ulcers by inducing changes in inflammatory microenvironment, especially through increased TGF-beta release: A pilot clinical and translational study
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
A cohort of 19 patients affected by chronic venous ulcers was recruited from our centre. A 4-mm punch biopsy from wound bed was taken before application of ALA 20% gel and repeated one hour after the first PDT irradiation. We observed a significant and progressive reduction of wounds mean volumes right after three ALA-PDT sessions (once per week; 4479.9â¯+/ââ¯345.5â¯mm3 vs 34599â¯+/ââ¯190.3â¯mm3, pâ¯<â¯.01). On immunofluorescence staining from biopsy specimens, we observed a change in all tested stains of post treatment specimens compared to pre-treatment ones. An increase of plasmacytoid dendritic cells (from 699â¯+/ââ¯22 cells/0.018â¯mm2 to 1369â¯+/ââ¯27 cells/0.018â¯mm2, pâ¯<â¯.0001); MHC-II expression (260.39â¯+/ââ¯99.7 Red, Green, Blue [RGB 0-255] to 370.2â¯+/ââ¯162.6 RGB (0-255), pâ¯<â¯.01), TNF-alpha positive mast cells expression (49â¯+/ââ¯0.3 cells/0.018â¯mm2 to 69â¯+/ââ¯0.4 cells/0.018â¯mm2, pâ¯<â¯.001), TGF-beta expression (59.89â¯+/ââ¯23.2 RGB (0-255)/cell vs 137.39â¯+/ââ¯56.6 RGB (0-255)/cell, pâ¯<â¯.01) and CD4+/CD25+ Treg cells (39â¯+/ââ¯1 cells/0.018â¯mm2 vs 209â¯+/ââ¯10 cells/0.018â¯mm2, pâ¯<â¯.001) was observed. An increase of TGF-beta was correlated in a statistical significant manner with a reduction of wounds' mean volumes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 21, March 2018, Pages 252-256
Journal: Photodiagnosis and Photodynamic Therapy - Volume 21, March 2018, Pages 252-256
نویسندگان
Vieri Grandi, Stefano Bacci, Alessandro Corsi, Maurizio Sessa, Elisa Puliti, Nicoletta Murciano, Francesca Scavone, Pietro Cappugi, Nicola Pimpinelli,