Un cas d'intoxication à la vancomycine traité avec succès par hémodialyse intermittente

We report a case of a 43 years old man who was intoxicated by a 25 g vancomycin overload. An anuric acute renal failure rapidly occured. The vancomycinemia was measured as high as 360 mg/L (normal range: 15-35 mg/L). We started an intermittent hemodialysis program to clear out the vancomycin. The vancomycinemia decreased below the treshold of our laboratory after the eighth session. Three supplementary sessions were needed because of a persistant oliguria. The kidney function slowly improved and was back to normal (seric creatinin: 80 micromol/L) 3 weeks after the patient had gone home. To our knowledge, it is the first success of this technic concerning vancomycin poisoning in adults with anuric kidney failure.