کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8775083 | 1599217 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibiteurs de la pompe à protons et rein
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کلمات کلیدی
Néphrite interstitielle aiguëacute kidney injury - آسیب حاد کلیهchronic kidney disease - بیماری مزمن کلیویDrug toxicity - سمیت مواد مخدرToxicité médicamenteuse - سمیت مواد مخدرProton pump inhibitor - مهار کننده پمپ پروتونinhibiteur de la pompe à protons - مهارکننده پمپ پروتونInsuffisance rénale aiguë - نارسایی حاد کلیهInsuffisance rénale chronique - نارسایی مزمن کلیهAcute interstitial nephritis - نفریت بینابینی حاد
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Assumed for a long time to be very well tolerated, proton pump inhibitors (PPIs) are widely prescribed for inpatients and outpatients; often beyond their validated indications. Nevertheless, many very varied side effects (pneumopathy, ischemic heart disease, dementia) have been associated with the PPIs during the last decade. Renal toxicity is mainly the occurrence of acute interstitial nephritis (AIN), related to a drug-class effect, involving cellular immunity. AINs, which occur especially in elderly patients, can be difficult to diagnose, with frequently isolated acute kidney injury, appearing with variable delay after the introduction of PPIs. Although sensitive to steroid therapy, patients frequently have an incomplete recovery of the kidney function. Very recently, the risk of chronic kidney disease (CKD) and the risk of progression of CKD among PPIs users have been well demonstrated in several large independent epidemiological studies. It is a low, but a significant side effect because of the millions of PPI prescriptions. Although further studies are needed to investigate the pathophysiological mechanisms leading the use of PPI to CKD, it is appropriate for the physicians to limit PPIs to their correct indications and to monitor renal function during these treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Néphrologie & Thérapeutique - Volume 14, Supplement 1, April 2018, Pages S115-S124
Journal: Néphrologie & Thérapeutique - Volume 14, Supplement 1, April 2018, Pages S115-S124
نویسندگان
Geoffroy Desbuissons, Gilbert Deray, Lucile Mercadal,