Portadoras de mutaciones en BRCA1 y 2 en familias de alto riesgo del área de Ciudad Real (España): prevalencia mutacional y características clínico-patológicas del cáncer de mama y ovario

In our analysis, the prevalence of mutations was higher in BRCA2 than in BRCA1, in agreement with some previous national studies. The clinical-pathological characteristics of breast/ovarian cancer in the carriers of these mutations were similar to the profile described in the literature.