کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8785785 | 1601089 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin D in melanoma: Controversies and potential role in combination with immune check-point inhibitors
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
However, recent evidence suggests that vitamin D exerts both anti-proliferative effects on tumor cells and immune-modulating activities, that have been widely explored in auto-immune disorders. On the one hand, vitamin D has been shown to inhibit T-helper17 lymphocytes, notoriously involved in the pathogenesis of immune-related adverse events (iAEs) which complicate immune-checkpoint inhibitor (ICI) treatment. On the other hand, vitamin D up-regulates PDL-1 expression on both epithelial and immune cells, suggesting a synergic effect in combination with ICIs, for which further investigation is needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 69, September 2018, Pages 21-28
Journal: Cancer Treatment Reviews - Volume 69, September 2018, Pages 21-28
نویسندگان
Luigia Stefania Stucci, Stella D'Oronzo, Marco Tucci, Antonella Macerollo, Simone Ribero, Francesco Spagnolo, Elena Marra, Virginia Picasso, Laura Orgiano, Riccardo Marconcini, Francesco De Rosa, Lorenza Di Guardo, Giulia Galli, Sara Gandini,