کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8787390 | 1601582 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The novel roles of stromal fibroblasts in metronomic chemotherapy: Focusing on cancer stemness and immunity
ترجمه فارسی عنوان
نقش های جدید فیبروبلاست های استروما در شیمی درمانی مترونومی: تمرکز بر سرطان و ایمنی
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کلمات کلیدی
فیبروبلاست های مرتبط با سرطان شیمی درمانی مترونومیک، سرطان سرطان، سلول های سرکوبگر مشتق از میلوئید،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Metronomic chemotherapy involves the administration of cytotoxic chemotherapy at reduced doses administered at regular and frequent intervals. Low-dose metronomic (LDM) chemotherapy represents an alternative to standard maximum tolerated dose (MTD) chemotherapy as it is less toxic and offers additional beneficial biological effects; such effects include inhibition of tumor neovascularization and reduced recruitment of immune-suppressive cells. In desmoplastic cancers such as breast and pancreatic cancers, carcinoma-associated fibroblasts (CAFs) in the tumor stroma constitute an important cellular target of systemic chemotherapy, and the treatment-modulated CAFs may deleteriously influence treatment efficacy. Herein, we reviewed the novel roles of CAFs in metronomic chemotherapy in desmoplastic cancers. We discuss the differential effects of MTD- and LDM-chemotherapy on the heterotypic interactions among CAFs and cells in the other cancer compartments, emphasizing the roles of cancer stem cells and myeloid-derived suppressor cells. The novel mechanistic roles of CAFs in cancer therapy provide an additional rationale for the clinical development of LDM chemotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cancer Research and Practice - Volume 4, Issue 4, December 2017, Pages 123-126
Journal: Journal of Cancer Research and Practice - Volume 4, Issue 4, December 2017, Pages 123-126
نویسندگان
Wen-Ying Liao, Tze-Sian Chan, Kelvin K. Tsai,