کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8787422 | 1601584 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Durable response to programmed death-1 (PD-1) blockade in a metastatic gastric cancer patient with mismatch repair deficiency and microsatellite instability
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
Mismatch repair deficiency (dMMR) or microsatellite instability (MSI) has been reported as a predictive biomarker for responses to programmed death-1 (PD-1) blockade in metastatic colorectal cancer. A high response rate to anti-PD-1 therapy was observed in other cancer types with MSI. We report a chemotherapy-refractory metastatic gastric cancer patient with dMMR and MSI who responded remarkably well to pembrolizumab, a PD-1 monoclonal antibody. The satisfactory objective response has lasted for more than 24 months as of this report.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cancer Research and Practice - Volume 4, Issue 2, June 2017, Pages 72-75
Journal: Journal of Cancer Research and Practice - Volume 4, Issue 2, June 2017, Pages 72-75
نویسندگان
Ting-Hui Wu, Emily Han-Chung Hsiue, Chang-Tsu Yuan, Li-Hui Tseng, Chia-Chi Lin, Kun-Huei Yeh,