کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8807281 | 1606595 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mesenchymal stem cell therapy in Parkinson's disease animal models
ترجمه فارسی عنوان
درمان سلول های بنیادی مزانشیمی در مدل های حیوانات بیماری پارکینسون
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
چکیده انگلیسی
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, and as a consequence, by decreased dopamine levels in the striatum. Currently available therapies are not able to stop or reverse the progression of the disease. A novel therapeutic approach is based on cell therapy with stem cells, in order to replace degenerated neurons. Among stem cells, mesenchymal stem cells seemed the most promising thanks to their capacities to differentiate toward dopaminergic neurons and to release neurotrophic factors. Indeed, mesenchymal stem cells are able to produce different molecules with immunomodulatory, neuroprotective, angiogenic, chemotactic effects and that stimulate differentiation of resident stem cells. Mesenchymal stem cells were isolated for the first time from bone marrow, but can be collected also from adipose tissue, umbilical cord and other tissues. In this review, we focused our attention on mesenchymal stem cells derived from different sources and their application in Parkinson's disease animal models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Research in Translational Medicine - Volume 65, Issue 2, AprilâJune 2017, Pages 51-60
Journal: Current Research in Translational Medicine - Volume 65, Issue 2, AprilâJune 2017, Pages 51-60
نویسندگان
A. Gugliandolo, P. Bramanti, E. Mazzon,