کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8838076 1613067 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional and structural plasticity contributing to obesity: roles for sex, diet, and individual susceptibility
ترجمه فارسی عنوان
پوسیدگی عملکردی و ساختاری کمک به چاقی: نقش جنسی، رژیم غذایی و حساسیت فردی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
The role of cortico-striatal pathways in cue-triggered motivational processes have been extensively studied. However, recent work has begun to examine the potential contribution of plasticity in these circuits to obesity. Despite the inclusion of women in human obesity studies examining neurobehavioral alterations in cue-triggered motivation, preclinical studies have focused mainly on male subjects. This lack of female subjects in preclinical research had led to a gap in the basic understanding of the neural mechanisms underlying over-eating in females. In this review, we highlight recent work from our lab and others that has begun to elucidate how diet, obesity, and individual susceptibility to weight gain influence functional and structural plasticity within the nucleus accumbens and prefrontal cortex in adult rats. As is the case throughout neuroscience, studies of females or sex differences are largely lacking in this area. Thus, below we describe preliminary neurobehavioral results from female studies in our labs and point out areas for future investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Behavioral Sciences - Volume 23, October 2018, Pages 160-170
نویسندگان
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