کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838098 | 1613068 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain mechanisms mediating effects of stress on reward sensitivity
ترجمه فارسی عنوان
مکانیسم های مغز می تواند اثرات استرس بر حساسیت پاداش را ارزیابی کند
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Acute and chronic stress have dissociable effects on reward sensitivity, and a better understanding of these effects promises to elucidate the pathophysiology of stress-related disorders, particularly depression. Recent preclinical and human findings suggest that stress particularly affects reward anticipation; chronic stress perturbates dopamine signaling in the medial prefrontal cortex and ventral striatum; and such effects are further moderated by early adversities. Additionally, a systems-level approach is uncovering the interplay among striatal, limbic and control networks giving rise to stress-related, blunted reward sensitivity. Together, this cross-species confluence has not only enriched our understanding of stress-reward links but also highlighted the role of neuropeptides and opioid receptors in such effects, and thereby identified novel targets for stress-related neuropsychiatric disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Behavioral Sciences - Volume 22, August 2018, Pages 106-113
Journal: Current Opinion in Behavioral Sciences - Volume 22, August 2018, Pages 106-113
نویسندگان
Maria Ironside, Poornima Kumar, Min-Su Kang, Diego A Pizzagalli,