کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8838977 | 1613220 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sexually diergic hypothalamic-pituitary-adrenal axis responses to selective and non-selective muscarinic antagonists prior to cholinergic stimulation by physostigmine in rats
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کلمات کلیدی
ACTHBNSTCRHeCBMPFCN-methyl-d-aspartateNMDAAUC - AUCendocannabinoid - آندوکانابینوئیدACh - آهAcetylcholine - استیل کولینgamma-aminobutyric acid - اسید گاما آمینو بوتیریکanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceintraperitoneal - داخل صفاقیCNS - دستگاه عصبی مرکزیblood brain barrier - سد خونی مغزیBBB - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیPhysostigmine - فیزیستیگمینmedial prefrontal cortex - قشر غده پروسترولmethoctramine - متاکترامینarea under the curve - منطقه تحت منحنیHPA - میلی بار یا هکتوپاسکالknockout - ناکاوتnorepinephrine - نوراپی نفرینbed nucleus of the stria terminalis - هسته تخت ترمینال های استریadrenocorticotropic hormone - هورمون adrenocorticotropiccorticotropin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینhypothalamic-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالCORT - کورتCorticosterone - کورتیکوسترونGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Central cholinergic systems regulate the hypothalamic-pituitary-adrenal (HPA) axis differentially in males and females (sexual diergism). We previously investigated the role of muscarinic receptors in this regulation by administering physostigmine (PHYSO), an acetylcholinesterase inhibitor, to male and female rats pretreated with scopolamine (SCOP), a nonselective muscarinic antagonist. SCOP pretreatment enhanced adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses in both sexes, but males had greater ACTH responses while females had greater CORT responses. In the present study, we further explored the role of muscarinic receptor subtypes in HPA axis regulation by administering PHYSO to male and female rats following SCOP or various doses of either the M1 or the M2 selective muscarinic receptor antagonists, pirenzepine (PIREN) or methoctramine (METHO). Blood was sampled before and at multiple times after PHYSO. ACTH and CORT were determined by highly specific immunoassays. M1 antagonism by PIREN prior to PHYSO resulted in sustained, dose-dependent increases in ACTH and CORT: ACTH responses were similar in both sexes, and CORT responses were greater in females. M2 antagonism by METHO prior to PHYSO resulted in overall decreases in ACTH and CORT: ACTH and CORT responses were higher in females but lower in both sexes than the hormone responses following PIREN or SCOP pretreatment. Area under the curve analyses supported these findings. These results suggest that specific muscarinic receptor subtypes differentially influence the HPA axis in a sexually diergic manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 137, March 2018, Pages 23-34
Journal: Brain Research Bulletin - Volume 137, March 2018, Pages 23-34
نویسندگان
Marissa A. Smail, Jessica L. Soles, Tracy E. Karwoski, Robert T. Rubin, Michael E. Rhodes,