کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840768 | 1614697 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons
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کلمات کلیدی
OTRTBSTDMSO - DMSOTris-buffered saline with Tween 20 - Tris-buffered saline با Tween 20Stress - استرس یا فشار روانیoxytocin - اکسیتوسینANOVA - تحلیل واریانس Analysis of varianceone-way analysis of variance - تحلیل واریانس یک راههTUNEL - تونلApoptosis - خزان یاختهایDIV - دیوDimethyl sulfoxide - دیمتیل سولفواکسیدday in vitro - روز in vitroCORT - کورتCorticosterone - کورتیکوسترونoxytocin receptor - گیرنده اکسی توسینglucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons](/preview/png/8840768.png)
چکیده انگلیسی
Stress is an adaptive and coordinated response to endogenous or exogenous stressors that pose an unpleasant and aversive threat to an individual's homeostasis and wellbeing. Glucocorticoids, corticosterone (CORT) in rodents and cortisol in humans, are adrenal steroids which are released in response to stressful stimuli. Although they help individuals to cope with stress, their overexposure in animals has been implicated in hippocampal dysfunction and neuronal loss. Oxytocin (OT) plays an active role in adaptive stress-related responses and protects hippocampal synaptic plasticity and memory during stress. In this study, we showed that OT protects primary mouse hippocampal neurons from CORT-induced apoptosis. OT receptors (OTR) were expressed in primary mouse hippocampal neurons and glial cells. CORT induced apoptosis in hippocampal neurons, but had no effect on apoptosis in glial cells. OT inhibited CORT-induced apoptosis in primary hippocampal neurons. OT was unable to protect primary hippocampal neurons prepared from OTR KO mice from CORT-induced apoptosis. These results indicate that OT has inhibitory effects on CORT-induced neuronal death in primary hippocampal neurons via acting on OTR. The findings suggest a therapeutic potential of OT in the treatment of stress-related disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 379, 21 May 2018, Pages 383-389
Journal: Neuroscience - Volume 379, 21 May 2018, Pages 383-389
نویسندگان
Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsui,