کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841045 | 1614705 | 2018 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice
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کلمات کلیدی
MEASGZPRLMPFCHNSCCGCLstratum oriensbasolateral amygdaloid complexENTshRNABLACeA - CEAshort-hairpin RNA - RNA کوتاه موی سرstratum radiatum - stratat radiatumstratum pyramidale - اهرام قهرمانcornu ammonis - بال آمونAlzheimer’s disease - بیماری آلزایمرSex differences - تفاوت های جنسیتیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیCognition - شناختdentate gyrus - شکنج دندانه دارinfralimbic cortex - قشر infralimbicEntorhinal cortex - قشر انتورینالmedial prefrontal cortex - قشر غده پروسترولdorsal peduncular cortex - قشر پشتی پشتیprelimbic cortex - قشر پیش از قاعدگیstratum lacunosum moleculare - لاکونوسوم سلولی مولکولیgranule cell layer - لایه سلول گرانولmolecular layer - لایه مولکولیVentral subiculum - مقعدی شکمیsubgranular zone - منطقه غده گرانولیHippocampus - هیپوکامپ Learning and memory - یادگیری و حافظه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DEK, a chromatin-remodeling gene expressed in most human tissues, is known for its role in cancer biology and autoimmune diseases. DEK depletion in vitro reduces cellular proliferation, induces DNA damage subsequently leading to apoptosis, and down-regulates canonical Wnt/β-catenin signaling, a molecular pathway essential for learning and memory. Despite a recognized role in cancer (non-neuronal) cells, DEK expression and function is not well characterized in the central nervous system. We conducted a gene ontology analysis (ToppGene), using a cancer database to identify genes associated with DEK deficiency, which pinpointed several genes associated with cognitive-related diseases (i.e., Alzheimer's disease, presenile dementia). Based on this information, we examined DEK expression in corticolimbic structures associated with learning and memory in adult male and female mice using immunohistochemistry. DEK was expressed throughout the brain in both sexes, including the medial prefrontal cortex (prelimbic, infralimbic and dorsal peduncular). DEK was also abundant in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex. Of note, compared to males, females had significantly higher DEK immunoreactivity in the CA1, indicating a sex difference in this region. DEK was co-expressed with neuronal and microglial markers in the CA1 and DG, whereas only a small percentage of DEK cells were in apposition to astrocytes in these areas. Given the reported inverse cellular and molecular profiles (e.g., cell survival, Wnt pathway) between cancer and Alzheimer's disease, these findings suggest a potentially important role of DEK in cognition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 254-267
Journal: Neuroscience - Volume 371, 10 February 2018, Pages 254-267
نویسندگان
Valentina Ghisays, Elizabeth T. Nguyen, Joshua Streicher, Nicholas A. Pease, Maureen Fitzgerald, Christina M. Estrada, Ana Franco-Villanueva, Lisa Privette Vinnedge, Matia B. Solomon,