کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841166 | 1614707 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons
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کلمات کلیدی
AAVsTSSING1piRNAsshRNApiwi-interacting RNAs - RNA های تعامل می کنندshort-hairpin RNA - RNA کوتاه موی سرEpigenetics - اپی ژنتیکchromatin immunoprecipitation - ایمن سازی کروماتینAdeno-associated viral vectors - بردارهای ویروسی Adeno مرتبطDNA repair - ترمیم DNAGene regulation - تنظیم ژنcoding sequence - توالی کدگذاریtranscription start site - رونویسی شروع سایتNeuronal activation - فعال سازی نورونCHiP - چیپCdS - کادمیم سولفید، سولفید کادمیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Epigenetic regulation of activity-induced gene expression involves multiple levels of molecular interaction, including histone and DNA modifications, as well as mechanisms of DNA repair. Here we demonstrate that the genome-wide deposition of inhibitor of growth family member 1 (ING1), which is a central epigenetic regulatory protein, is dynamically regulated in response to activity in primary cortical neurons. ING1 knockdown leads to decreased expression of genes related to synaptic plasticity, including the regulatory subunit of calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream of the transcription start site (TSS) of Ppp3r1 depends on yet another group of neuroepigenetic regulatory proteins, the Piwi-like family, which are also involved in DNA repair. These findings provide new insight into a novel mode of activity-induced gene expression, which involves the interaction between different epigenetic regulatory mechanisms traditionally associated with gene repression and DNA repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 369, 15 January 2018, Pages 248-260
Journal: Neuroscience - Volume 369, 15 January 2018, Pages 248-260
نویسندگان
Laura J. Leighton, Qiongyi Zhao, Xiang Li, Chuanyang Dai, Paul R. Marshall, Sha Liu, Yi Wang, Esmi L. Zajaczkowski, Nitin Khandelwal, Arvind Kumar, Timothy W. Bredy, Wei Wei,