کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841529 | 1615024 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressant effects of acupoint stimulation and fluoxetine by increasing dendritic arborization and spine density in CA1 hippocampal neurons of socially isolated rats
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کلمات کلیدی
DRN5HTCA15-hydroxytryptamineFSTForced swimming test - آزمون اجباری شناDepression - افسردگیSocial isolation - انزوای اجتماعیcornu ammonis - بال آمونanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceStudent-Newman-Keuls - دانش آموز-نیومن-کولpostnatal day - روز پس از زایمانAcupuncture - طب سوزنی Fluoxetine - فلوکستینSelective serotonin reuptake inhibitor - مهار کننده بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینdorsal raphe nucleus - هسته رافهHippocampus - هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Given the importance of depression and the adverse effects of conventional treatment, it is necessary to seek complementary therapies. In a rat model of depression, this study aimed to assess the behavioral and morphological effects of embedding absorbable thread in acupoints (acu-catgut), and compare the results to those of fluoxetine treatment and the corresponding control groups. Therefore, depressive-like behavior was evaluated with the forced swimming test, and dendritic morphology (in the CA1 hippocampal region) with the Golgi-Cox technique and Sholl analysis. After weaning, male Sprague-Dawley rats were housed in social isolation for 8 weeks to induce depressive-like behavior. They were then given a 21-day treatment by stimulating acupoints with acu-catgut (AC) or fluoxetine (FX) (2â¯mg/kg). Rats were divided into six groups: Control (socially housed), social isolation (SI), SIâ¯+â¯AC, SIâ¯+â¯Sham (sham embedding of thread), SIâ¯+â¯FX and SIâ¯+â¯VH (vehicle). Compared to fluoxetine, acu-catgut treatment was more effective in reversing depressive-like behavior elicited by SI. The SI-induced reduction in dendritic length and spine density in hippocampal CA1 pyramidal neurons was attenuated after prolonged treatment with acu-catgut or fluoxetine. Hence, both treatments proved capable of reversing depressive-like alterations caused by SI, likely due to dendritic remodeling in the hippocampus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 675, 14 May 2018, Pages 48-53
Journal: Neuroscience Letters - Volume 675, 14 May 2018, Pages 48-53
نویسندگان
Amalia Dávila-Hernández, Sergio R. Zamudio, LucÃa MartÃnez-Mota, Roberto González-González, Eduardo RamÃrez-San Juan,